Fluimucil antibiotic it for inhalation side effects. Fluimucil antibiotic it. With inhalation use are also possible.
Fluimucil antibiotic IT instruction: by application.
A complex remedy with antibiotic properties, mucolytic.
Composition, release form
Fluimucil antibiotic is available as a lyophilisate (powder).
The glass vial contains 810 mg of the drug, including the antibiotic thianfenicol and acetylcysteine glycinate, of which thiamphenicol is 500 mg.
After inhalation of small particles of the sprayed medicine, the patient will feel the effect of the drug. The drug will be inhaled, bypassing other organs. Those are its applicable local, not general. This medicine is a huge plus. Another advantage of this tool is that by making the solution for inhalation by spraying and not using it completely, you can put the medicine in the refrigerator until the next time. That's great, you don't have to throw away unused medications, which is often the case with other drugs.
Negative reviews about the drug
And you can leave the refrigerator of yesterday's solution the next day, heat it up and inhale with it. Some people are outraged that this means a disadvantage for them. After 1 package, you will have to pay about 600 rubles. However, given the influence of this agent, the price is not a criterion for which attention should be paid. Moreover, the health of a loved one is more expensive, but priceless. Also, some patients don't like the fact that this means you have to buy more and a special device called an inhalation nebulizer.
An additional component is disodium edetet. As a solvent, distilled water is used, packaged in separate ampoules.
pharmachologic effect
The therapeutic effect of the complex drug Fluimucil antibiotic is due to thiamphenicol and acetylcysteine.
Tiamphenicol is an antibiotic active against staphylococci, streptococci, Neisseria, Klebsiella spp., Haemophilus influenza.
Composition and action on the body
But here, as it turns out, there is a way. However, when used orally, the speed of action of the drug will not be the same as in the case of inhalation. Thus, it is better to buy a nebulizer and therapy with this device. And do not think that after treatment you do not need a larger body. After all, it can be used not only to treat bronchitis, pharyngitis and pneumonia, but a common cough is a symptom of acute respiratory viral infections. Some people post on the forums about bad smell sulfur-like drug.
Thiamphenicol is highly effective against bacteria, disease-causing respiratory organs, ENT organs - frontal sinusitis, rhinitis, sinusitis.
The drug has a pronounced effect on infections of the respiratory system with a viscous purulent discharge.
When are inhalations with Fluimucil contraindicated?
However, nothing can be done, you just get used to this "taste" to the oldest and suffer a week after 7 days, according to many people, the disease recedes. Its main advantage is that it is used for inhalation and thus quickly reaches the necessary organs, thereby bypassing the gastrointestinal tract and does not harm it.
Galenic form and amount of active ingredient per unit
it effective drug, as evidenced by the many online reviews of people getting drug data. Professional information of the Swiss Compendium of Medicine®. Active ingredient: acetylcysteine. Ampoule: 300 mg of acetylcysteine about 3 ml.
Helps with prolonged pneumonia that is not treatable with other antibiotics.
The activity of the drug is observed against Streptococcus pneumonia, Staphylococcus spp., Corynebacterium diphtheria, Listeria monocytogenes. Thiamphenicol acts on pathogens of salmonellosis, shigellosis, whooping cough, brucellosis, plague.
The mucolytic effect of acetylcysteine is manifested in thinning, reducing the viscosity of sputum, pus.
In the case of respiratory diseases characterized by dense and viscous hypersecretion, it is difficult to expectorate. Pneumology: all forms of bronchitis, emphysema, atelectasis, bronchiectasis, cystic fibrosis. Surgery: Prevention of bronchopulmonary complications with mucositis.
Like mucolytic intensive care
Poisoning: An antidote for paracetamol poisoning. Pediatrics: bronchitis, cystic fibrosis. Flushing other body cavities: ½ ampoule per application.
Antidote for paracetamol poisoning
For this special application more than 20% of vials. The following treatment regimen is recommended. Patients weighing ≥40 kg. Patients weighing 20 to 40 kg. Patients weighing less than 20 kg. It is also possible to deliver a faster initial bolus within 15 minutes, but slow bolus delivery reduces the chance of anaphylactoid reactions.Fluimucil antibiotic is excreted by the kidneys, a small part of the compound is excreted through the gastrointestinal tract. The drug crosses the placenta during pregnancy.
Indications
- Diseases of the ENT organs - otitis media, sinusitis (sinusitis,), laryngotracheitis.
- Bronchitis, pneumonia, lung abscess, bronchiolitis, cystic fibrosis, whooping cough.
- Nonspecific respiratory, mycobacterial infections.
- Prevention of complications during operations on the bronchi, trachea, lungs.
Contraindications
Fluimucil antibiotic IT is not prescribed for anemia, diseases of the hematopoietic system, diseases of the liver, kidneys.
With inhalation use, it is also possible
Children: in infants and early age under the age of one year, the product should only be administered under the supervision of a physician as part of inpatient treatment. In children under 6 years of age, treatment with suitable oral forms is preferred over parenteral therapy.
Hypersensitivity to acetylcysteine or any of the excipients according to the composition. Intravenous administration of acetylcysteine should be carried out under strict medical supervision. Adverse events associated with acetylcysteine therapy are more likely to occur when administration is too rapid or excessive. Therefore, it is recommended to strictly observe the dosage.
Do not use in case of individual intolerance.
Caution is used in patients with bronchial asthma due to the risk of increased bronchospasm.
Fluimucil antibiotic is used with caution in children under 2 years of age due to age-related developmental features and kidney function.
In patients over 65 years of age, the content of leukocytes in the blood is monitored during treatment. When the number of leukocytes falls below the norm - 4 thousand / cm 3, the drug is canceled.
In patients weighing less than 40 kg, the antidote should be used with caution due to the potential risk of hypervolemia, which can lead to hyponatremia and seizures. With direct intravenous use at high doses, pseudoanaphylactic reactions have sometimes been observed.
Contraindications and side effects
For this reason, patients should be monitored and adequate therapeutic measures should be taken at the onset of the first symptoms. Simultaneous administration of a cough suppressant by eliminating the cough reflex and physiological self-clearing of the airways leads to mucus stasis with the risk of developing bronchospasm and respiratory tract infection.
Application
Fluimucil antibiotic IT is used for inhalation, intramuscular injection, washing of paranasal sinuses, body cavities, applications.
Inhalations
- adults - 1-2 times a day, 250 mg;
- children - up to 2 times a day, 125 mg.
According to patients, 3-4 inhalations with fluimucil antibiotic IT are enough to feel relief.
Side effects of inhaled Fluimucil
Patients with bronchial asthma should be carefully monitored during treatment. If bronchospasm occurs, acetylcysteine should be discontinued and appropriate therapeutic measures taken. Caution is advised in patients at risk of gastrointestinal bleeding, especially when used in combination with other drugs that cause irritation of the gastric mucosa.
Low Sodium Diet Information
Administration of acetylcysteine may prolong prothrombin time, in addition to the toxicity of paracetamol. With the simultaneous administration of glycerol nitrate, the effect of a vasodilator and inhibition of platelet aggregation may increase. The clinical significance of these results has not yet been determined.
Intramuscular
In newborns and the elderly, the dosage is not increased. The course of treatment is 10 days.
If co-treatment with parenteral nitroglycerin and acetylcysteine is necessary, the patient should be monitored for any risk of hypotension, which may be severe and may present as headache. Data for a limited number of infected pregnant women did not reveal negative consequences for pregnancy or the health of the fetus or newborn.
Effects on the ability to drive and use machines
There are no experiments in epidemiological studies. Caution is advised when used during pregnancy. There are no studies on the passage of acetylcysteine in breast milk. The effect on the ability to drive and use machines has not been tested.
local use
Locally, an antibiotic is used to wash the paranasal sinuses, instilled into the ears and nose for ENT diseases.
For instillation into the ear canal and nose, fluimucil antibiotic is diluted:
- adults - 500 mg of lyophilisate in 4 ml of distilled water from an ampoule;
- children - 250 mg of lyophilisate in 4 ml of water.
Instill 4 drops into the nose or ear canal.
The most commonly reported adverse reactions in the literature for intravenous acetylcysteine are rash, urticaria, and pruritus. They occur most frequently during the initial bolus delivery. In a randomized, open-label, and multicenter study, the following adverse events occurred within the first 2 hours after administration of acetylcysteine.
Immune system disorders
Very common: anaphylactoid reaction. Sometimes: pharyngitis, rhinorrhea, wheezing, bronchospasm. General: vomiting, nausea. General: itching, rash. The following adverse reactions have been reported based on long-term post-marketing experience and their frequency cannot be estimated from the available data.
Reception features
Fluimucil antibiotic for inhalation is not taken simultaneously with cough suppressants. This causes mucus stagnation. The drug is taken separately from other medicines.
System administration
Respiratory organs: bronchospasm, rhinorrhea. Gastrointestinal disorders: stomatitis, vomiting. Skin diseases: angioedema, urticaria, rash, itching. Cardiac disorders: tachycardia. Respiratory organs: bronchospasm, shortness of breath. Gastrointestinal disorders: vomiting, nausea.
Skin diseases: angioedema, urticaria, redness of the face, rash, itching. General disorders and site administration conditions: swelling of the face. Investigations: hypotension, prolongation of prothrombin time. The occurrence of serious skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome has been reported very rarely in a temporal relationship with the use of acetylcysteine. In case of new manifestations of skin manifestations and in the mucous membranes, it is recommended to immediately consult a doctor and discontinue the use of acetylcysteine.
The prepared fluimucil antibiotic for inhalation should be protected from contact with metal, rubber objects, the drug is diluted in a glass container.
During pregnancy
Fluimucil antibiotic is prescribed during pregnancy in exceptional cases, only on the recommendation of a doctor. During lactation, the drug is not recommended.
In most of these cases, at least one other drug was used at the same time and could eventually potentiate the observed mucosal effects. Various studies confirm the reduction in platelet aggregation with the use of acetylcysteine. The clinical significance of this effect is unclear.
Mechanism of action and pharmacodynamics
In case of overdose, stop the infusion and start symptomatic treatment. There is no specific antidote treatment. Acetylcysteine is dialyzed. No cases of overdose have been reported to local authorities. The mucolytic effect of acetylcysteine is based on the ability of the thiol group to reduce the disulfide bridges of the mucous mucoprotein acid.
Side effects
When taking, an allergy is possible. Inhalations of fluimucil antibiotic can cause coughing, irritation of the bronchial mucosa. Nausea, stomatitis are noted. In rare cases, bronchospasm is observed.
Electrophilic compounds are inactivated by conjugation, oxidizing compounds are neutralized by reduction. Through cysteine, acetylcysteine is a major precursor to glutathione synthesis and therefore increases endogenous glutathione reservoirs. Glutathione is an important nucleophilic and antioxidant active substance in the body and has great importance for his protection. In addition, in certain poisonings, glutathione can inactivate toxic, reactive, and electrophilic metabolites through the formation of inert complexes.
Intramuscular injections can cause burning at the injection site. With this method of using the drug, anemia, a change in the blood count, expressed in a decrease in the number of platelets, leukocytes, and neutrophils, are noted.
Drug overdose
Self-medication is unacceptable, the result of an overdose and uncontrolled use of the drug may be superinfection, increased side effects, change of own bacterial microflora.
Thus, breathing becomes easier. He can also provide positive influence on other clinical parameters such as dyspnea and lung function. After intravenous administration, acetylcysteine rapidly dissipates in the body, mainly in the aqueous environment of the extracellular space, and reaches the highest concentrations in the liver, kidneys, lungs and bronchial mucosa.
In the body, acetylcysteine is either in free form or is bound to plasma proteins by reversible disulfide bridges. In neonates or patients with severe hepatic impairment, a longer half-life is expected. Approximately 30% of the administered dose is removed directly by the kidneys. The main metabolites are cystine and cysteine. In addition, small amounts of taurine and sulfates are excreted.
Storage
The drug is stored at a temperature of +15 o C ... +25 o C, the shelf life is 3 years.
Holiday conditions
It is sold in pharmacies by prescription, the price of a package of fluimucil antibiotic is 500-600 rubles.
Fluimucil antibiotic IT for inhalation is effective remedy against a large number of respiratory diseases caused by pathogenic and opportunistic bacteria.
Regarding the removal of the non-exclusive part, there is still no research. Mutagenic effects with acetylcysteine should not be expected. The results carried out on bacterial organisms gave negative results. Experiments on the carcinogenic potential of acetylcysteine have not been conducted.
Embryotoxicity studies have been performed in pregnant rabbits and rats given an oral dose of acetylcysteine during the gestation period. None of these experimental studies revealed fetal malformations. Fertility, peri- and postnatal studies were performed in rats with oral acetylcysteine. The results of these studies indicate that acetylcysteine does not adversely affect gonadal function, fertility, infants, or neonatal development.
The drug is produced by the Italian company Zambon SPA and still has no complete analogues.
It is a bottle with a white or light yellow mass, which must be diluted with the supplied water for injection before use. The package contains 3 ampoules of lyophilisate and solvent.
Indications for use: what helps Fluimucil?
The active ingredients of the drug are antibiotic a wide range the actions of thiamphenicol and the mucolytic agent acetylcysteine, which are part of it in the form of a complex compound of thiamphenicol glycinate acetylcysteinate.
It is intended for injections and inhalations, but in most cases, patients are prescribed inhalation therapy, since this significantly increases the safety and effectiveness of treatment.
Indeed, when inhaling a fine suspension of a drug, almost all of its particles fall directly on the inflamed surface of the mucous membrane, where they are most needed.
When choosing an injection method of administration, this advantage is lost, since the drug is carried by the blood throughout the body, and only part of it gets to the destination. 
Nevertheless, injections are also used, but they are shown mainly only in severe conditions of patients who need to take a large number of different drugs, and inhalations for one reason or another cannot be carried out.
Thiamphenicol prevents the formation of bacterial cell wall components, thereby leading to their death. Acetylcysteine also facilitates the process of its removal. 
In addition, it promotes the penetration of thiamphenicol into tissues and reduces the ability of microorganisms to attach to the surface of the mucous membrane.
Thus, Fluimucil-antibiotic IT exhibits antibacterial, mucolytic and anti-inflammatory pharmacological effects.
This is the reason for the prescription of the drug. It is widely used as part of complex therapy:
- acute and chronic inflammatory diseases of the NDP, that is, with bronchitis, pneumonia, laryngotracheitis;
- adenoiditis, whooping cough, cystic fibrosis, lung abscess, bronchiectasis, tuberculosis;
- complications after operations;
- otitis;
- acute and chronic sinusitis, rhinopharyngitis.
Taking the remedy is indicated during preparation for serious diagnostic and therapeutic manipulations on the respiratory organs, etc. It is also sometimes used to prevent the development of complications.
Only a doctor can prescribe inhalation therapy if there are strong indications for this! The shelf life of the drug is 3 years. But be sure to keep in mind that it retains its properties only at temperatures up to 25 ° C.
Sinusitis and Fluimucil antibiotic IT
The drug is very often used in ENT practice for sinusitis, and not only in the form of inhalation, but also as a means for professional washing of the paranasal sinuses.
But in order for the drug to have the maximum possible therapeutic effect, before its administration in one way or another, it is recommended, for example, Aquamaris, Marimer, Humer, Dolphin.
After that, vasoconstrictors are necessarily instilled, which can be any drugs based on oxymetazoline, xylometazoline, naphazoline, etc. But it is better to choose Rinofluimucil.
This drug not only perfectly eliminates edema, but also dilutes the remaining snot and accelerates their excretion. All this eliminates obstacles for the penetration of the antibiotic directly to the destination - the maxillary (maxillary) sinuses.
Features of drug interaction
The medication should not be combined with:
- antitussive drugs (Gedelix, Bronchipret, Sinekod, Codelac, Libexin, etc.);
- nitroglycerin;
- other medicines in the form of an aerosol.
Difference between Fluimucil and Fluimucil Antibiotic IT
Both medicines are produced by the Italian company Zambon SPA. The difference lies in their composition. So, the active substance of Fluimucil is only acetylcysteine, when thiamphenicol is additionally included in Fluimucil-antibiotic. This explains the difference in the action of drugs.
Fluimucil exhibits exclusively anti-inflammatory and mucolytic properties and in no way affects the viability of pathogens. Whereas Fluimucil-antibiotic actively suppresses their ability to grow and reproduce.
Thus, Fluimucil is mainly a symptomatic therapy and is used exclusively for diseases accompanied by a cough with poor sputum discharge. At the same time, the drug with an antibiotic has a much wider area of use.
How to do inhalations with Fluimucil in a nebulizer: instructions
Since the drug contains an antibiotic, inhalations can only be carried out in compression inhalers or nebulizers with a glass chamber..
If the patient is diagnosed with airway obstruction, but the use of Fluimucil-antibiotic is still required, bronchodilators are preliminarily taken (Berodual, Ventolin, Berotek, etc.). 
Preparation for inhalation consists in diluting the lyophilisate with the supplied solvent. Depending on the model of nebulizer used, it is sometimes recommended to replace 1 ml of water for injection with an equal amount of saline. Do this immediately before the procedure.
Attention
The first time you use it, you need to do an allergy test. To do this, the diluted product is applied to clean skin. inside forearm.
If neither after half an hour, nor after 2 hours, nor after a day, the skin condition has not changed (no rash, redness, itching, etc.),
To dilute the drug is necessary:
- remove the metal cap and rubber stopper from the lyophilizate vial;
- by pressing hard on the head or using a special nail file, open the ampoule with water for injection along the fault line (colored ring);
- pour the solvent into the vial and mix thoroughly.
Adults are shown taking 250 mg of the drug, which corresponds to 2 ml (half) of the prepared remedy, in one procedure. The remaining solution can be stored for a day in a bottle tightly sealed with a factory rubber stopper in the refrigerator.
Although many experts claim that it breaks down in water, therefore, it is advised to prepare a fresh solution before each inhalation.
From 2 to 4 inhalations should be carried out per day. Each one is approximately 15 minutes long. In the treatment of diseases of the nose and ear, such as sinusitis, otitis media, and others, it is worth using a special nasal inhaler nozzle.
To combat bacterial lesions of the lower respiratory tract, accompanied by a cough, a mouthpiece is more suitable.
The drug is canceled if the total blood pressure shows a decrease:
- the level of leukocytes up to 4000 units / μl and below;
- the number of granulocytes by 40% or more.
Fluimucil antibiotic IT for inhalation: how to breed for children?
Quite often, pediatricians prescribe Fluimucil for inhalation to a child. Indeed, it is not contraindicated in children, but up to 3 years it is used with great care, since only by this time the formation of kidneys is completed. Therefore, when treating babies under 3 years old, the dosage should be treated with particular scrupulousness.
The pediatric dosage for the nebulizer is 125 mg. To prepare a solution for inhalation, you must perform the above steps, maintaining the same proportions. 
But children for one procedure need to use only 1 milliliter of the finished solution. To achieve dosing accuracy, we recommend using an insulin syringe.
As with adults, children with severe respiratory problems are often given loading doses in the first 2–3 days of treatment. The exception is premature and newborn babies. For them, any excess of the therapeutic dose is dangerous. 
Children are usually inhaled through a mask that covers the mouth and nose at the same time. But if the child is already old enough to inhale the medicinal mixture through a nasal nozzle or mouthpiece, it is worth using them.
Depending on the severity of the pathology and the age of the patient, the procedures are carried out 2 or 3 times a day for several minutes for babies and up to 15 minutes for teenagers.
During pregnancy
Fluimucil for inhalation instructions, but only on condition that the planned benefit for the expectant mother is higher than the potential harm to the fetus.
This is due to the fact that with this method of administration, the drug practically does not penetrate into the systemic circulation and cannot harm the developing fetus.
But do not forget that acetylcysteine is able to pass through the placental barrier and affect the child. Therefore, visiting a doctor and obtaining his permission to conduct inhalation therapy mandatory for pregnant women.
Contraindications and side effects
The drug is prescribed with caution when:
- disorders of the bone marrow;
- severe pathologies of the liver and kidneys;
- exacerbations of stomach and duodenal ulcers;
- pulmonary bleeding, hemoptysis;
- bronchial asthma.
Although sometimes signs hypersensitivity appear only after 2 or 3 doses. Also, if there is a need for inhalation during lactation, from breastfeeding it is recommended to refuse for the entire duration of treatment.
As for the side effects, Fluimucil antibiotic IT is usually well tolerated, but in isolated cases, especially with an overdose, the appearance of:
- runny nose and reflex cough;
- bronchospasm (mainly in patients with bronchial asthma);
- stomatitis;
- nausea;
- rashes on the skin or swelling of the larynx, which is a symptom of intolerance to the components of the drug.
Analogues
The drug still has no complete analogues. You can only find a replacement for the usual Fluimucil, which contains only acetylcysteine. This substance acts as an agent in:
- Mukobene;
- Mucomix, etc.
However, if it is not possible to obtain this medicine, it can be replaced with other antibiotics suitable for inhalation.
But only a doctor should prescribe them, based on the characteristics of the course of the disease, the age of the patient, the presence of concomitant pathologies, etc.
Thus, Fluimucil antibiotic IT is good remedy to combat bacterial infections of the upper and lower respiratory tract, especially those accompanied by coughing.
